Healthcare & Senior Care Franchises for Sale in South Dakota up to $300,000

HealthSource Chiropractic: $363K Avg Gross Profit with Unmatched Care Nationwide! More info

EverSun by iTan — Efficient, automated beauty franchise with membership recurring revenue and minimal staffing. More info

ANY LAB TEST Now® is the nation's first retail, direct access lab testing company that offers thousands of lab test in one place. If you are interested in owning a business that allows consumers to take control of their health. Any Lab Test may for you. More info

Nation's largest assisted living/memory care franchise! 200+ locations in 20 states and growing. Come join 35+ years of experience! More info

Recognized in the 2026 Entrepreneur Franchise 500, Homewatch CareGivers is a recession resilient in-home care franchise where owners average $2,552,023** in gross revenue while building meaningful, impact driven usinesses. -resilient in-home care franchise where owners average $2,552,023-driven businesses. More info

QC Kinetix is the only nonsurgical medical franchise that provides customized Regenerative Medicine treatments. More info

Transform Lives with 101 Mobility; Make Helping Others Your Business! More info

For more than 20 years, Cruise Planners has been a low-cost franchise opportunity that can yield high returns! More info

Are you passionate about owning your own business? Are you interested in giving people the choice to eat healthy? If the answer is yes, then you have found the right partner to build you a successful healthy vending business. At Healthier4U Vending we share your passion and want you to join us to give the choice to eat healthy to everyone. Come see how together we can change your life. More info

Tap into the huge demand for fresh, custom-made pet foods by owning this top-ranked pet franchise. More info

First Choice Business Brokers are a team of passionate professionals that assist buyers and sellers of small to medium-sized businesses with their buying/selling transactions. With over 25 years of industry-leading experience, new franchise owners are expertly trained in a proven business model. This unique opportunity offers multiple streams of revenue by helping business owners. More info

Whether full-time or part-time, Mattress By Appointment is your easiest pathway to get out of your suit/tie 60 hour work week while earning more money! More info

To make a positive lasting impact on children and families through teaching the joy and value of cooking in a welcoming environment that encourages discovery and creativity. More info