Home Based Franchises for Sale in South Dakota over $500,000

The premiere provider of in-home care where you can provide a lasting impact for aging adults and their families. Over 300 franchise owners! Open within 90 days! More info

Dumpster Dudez - Choose Orange. Choose the Best. Choose Dumpster Dudez! More info

Ace Handyman Services, owned by Ace Hardware, is a home services business that focuses on solving customer's small to large size handyman projects in the home and commercial space. More info

Build a thriving senior care business with heart. Multiple revenue streams, award-winning support, and a mission that makes a difference. More info

20 Years as America's Leader in Medical Billing with Unparallelled Training, and Support. 100k Potential, Work From Anywhere, Full-Time or Part-Time. Come Join Our Success! More info

Moe's Southwest Grill® is authentic, adventurous and all-around fun. Our passion has made us the go-to brand for Southwestern fare and one of the most recognized fast-casual Mexican restaurant franchises available. We're the ideal choice for franchise owners interested in building a loyal following in their market while embracing their own independent spirit. More info

Aesthetic Development Group is an affordable, turnkey business opportunity, offering body contouring and facial rejuvenation service lines to both new and established practices. More info

Premium mobile coffee franchise from the makers of Kona Ice. Proven model, fixed royalties, and expert business support. Own your journey today! More info

Ranked as a top Junk-Removal Services franchise by 2026 Entrepreneur Franchise 500®. $553K average gross sales!* More info

Are you passionate about owning your own business? Are you interested in giving people the choice to eat healthy? If the answer is yes, then you have found the right partner to build you a successful healthy vending business. At Healthier4U Vending we share your passion and want you to join us to give the choice to eat healthy to everyone. Come see how together we can change your life. More info

Snapology is a leading children’s enrichment franchise focused on STEAM (Science, Technology, Engineering, Arts, and Math) education through hands-on, play-based learning. With programs that engage kids ages 4–14 through robotics, coding, animation, and themed building activities, Snapology makes learning fun and impactful. The mobile-friendly model offers flexibility and low overhead, making it an ideal opportunity for passionate entrepreneurs looking to bring meaningful educational experiences to their communities. Whether hosted in schools, community centers, or birthday parties, Snapology helps children build confidence, critical thinking skills, and a lifelong love of learning. More info

To make a positive lasting impact on children and families through teaching the joy and value of cooking in a welcoming environment that encourages discovery and creativity. More info