Home Based Franchises for Sale in Missouri over $500,000

Kiddie Academy® Domestic Franchising is based in Maryland and supports 350+ Academies and counting in 39 states and the District of Columbia. More info

20 Years as America's Leader in Medical Billing with Unparallelled Training, and Support. 100k Potential, Work From Anywhere, Full-Time or Part-Time. Come Join Our Success! More info

Premium mobile coffee franchise from the makers of Kona Ice. Proven model, fixed royalties, and expert business support. Own your journey today! More info

Average Gross Sales of $461,941!* Award-winning MaidPro is America’s most loved home cleaning franchise. Trusted for over 30 years by families and businesses alike. More info

Snapology is a leading children’s enrichment franchise focused on STEAM (Science, Technology, Engineering, Arts, and Math) education through hands-on, play-based learning. With programs that engage kids ages 4–14 through robotics, coding, animation, and themed building activities, Snapology makes learning fun and impactful. The mobile-friendly model offers flexibility and low overhead, making it an ideal opportunity for passionate entrepreneurs looking to bring meaningful educational experiences to their communities. Whether hosted in schools, community centers, or birthday parties, Snapology helps children build confidence, critical thinking skills, and a lifelong love of learning. More info

With more than 45 years of experience and hundreds of locations nationwide, Sylvan Learning is the leading provider of personalized education for students in grades K–12. Franchisees benefit from a trusted brand, proven business model, and powerful technology platform that supports individualized learning in reading, math, writing, study skills, STEM, and test prep. Backed by a national support team and ongoing innovation, Sylvan franchise owners make a lasting impact while building a scalable, rewarding business in the booming education sector. More info

Join the #1 mobile business with Kona Ice! Low overhead, high margins, and a community-loved brand that brings the party to every stop. More info

Tap into the huge demand for fresh, custom-made pet foods by owning this top-ranked pet franchise. More info

Ace Handyman Services, owned by Ace Hardware, is a home services business that focuses on solving customer's small to large size handyman projects in the home and commercial space. More info

Providing Compassionate and Dependable Home Care More info

We are the largest and fastest growing kids coding and stem concept in the world! With low start-up costs, a proven business model, best-in-class support across operations, technology, curriculum, and marketing, plus proprietary curriculum and products, Code Ninjas is the premier option in the youth enrichment business. More info

Molly Maid, a Neighborly company, is the nation's leading residential and commercial cleaning services franchise. With us, you'll get a polished approach to business ownership! More info