Home Based Franchises for Sale in Missouri over $500,000

Snapology is a leading children’s enrichment franchise focused on STEAM (Science, Technology, Engineering, Arts, and Math) education through hands-on, play-based learning. With programs that engage kids ages 4–14 through robotics, coding, animation, and themed building activities, Snapology makes learning fun and impactful. The mobile-friendly model offers flexibility and low overhead, making it an ideal opportunity for passionate entrepreneurs looking to bring meaningful educational experiences to their communities. Whether hosted in schools, community centers, or birthday parties, Snapology helps children build confidence, critical thinking skills, and a lifelong love of learning. More info

Moe's Southwest Grill® is authentic, adventurous and all-around fun. Our passion has made us the go-to brand for Southwestern fare and one of the most recognized fast-casual Mexican restaurant franchises available. We're the ideal choice for franchise owners interested in building a loyal following in their market while embracing their own independent spirit. More info

Whether full-time or part-time, Mattress By Appointment is your easiest pathway to get out of your suit/tie 60 hour work week while earning more money! More info

Micro markets are the future of break-rooms and these “automated convenience stores” are BOOMING! Key to your success is our growing brand recognition, training, and support. Not to mention that the Healthy Smart Mart™ proprietary payment kiosk and phone “app-based" payment system are cutting edge! More info

Experience the Healing Power of Hyperbaric Oxygen Therapy Backed by Research Guided by Trained Professionals Focused on You More info

For more than 20 years, Cruise Planners has been a low-cost franchise opportunity that can yield high returns! More info

Premium mobile coffee franchise from the makers of Kona Ice. Proven model, fixed royalties, and expert business support. Own your journey today! More info

Leading Residential Property Management Franchise Seeking Like Minded Candidates. We provide an opportunity in Property Mgmt for those seeking a residual income and the lifestyle that accompanies it. More info

Brew community and profit with Ziggi's Coffee-flexible formats, strong support, and high AUV in one of America's fastest-growing franchises. More info

Replace your income, or earn EXTRA INCOME and keep your job. Earn money 24/7 with HEALTHY VENDING. More info

Ranked #1 Plumbing franchise by 2026 Entrepreneur Franchise 500®. $2.09M average gross sales!* More info

Ranked as a top Residential Cleaning franchise by 2026 Entrepreneur Franchise 500®. 91% recurring customers!* More info