Business Opportunities for Sale in Missouri over $500,000

Ranked as a top Junk-Removal Services franchise by 2026 Entrepreneur Franchise 500®. $553K average gross sales!* More info

Touching Hearts at Home is one of the largest privately owned franchises in the Home Health industry. We help people age in place with dignity and care. More info

Snapology is a leading children’s enrichment franchise focused on STEAM (Science, Technology, Engineering, Arts, and Math) education through hands-on, play-based learning. With programs that engage kids ages 4–14 through robotics, coding, animation, and themed building activities, Snapology makes learning fun and impactful. The mobile-friendly model offers flexibility and low overhead, making it an ideal opportunity for passionate entrepreneurs looking to bring meaningful educational experiences to their communities. Whether hosted in schools, community centers, or birthday parties, Snapology helps children build confidence, critical thinking skills, and a lifelong love of learning. More info

Ace Handyman Services, owned by Ace Hardware, is a home services business that focuses on solving customer's small to large size handyman projects in the home and commercial space. More info

First Choice Business Brokers are a team of passionate professionals that assist buyers and sellers of small to medium-sized businesses with their buying/selling transactions. With over 25 years of industry-leading experience, new franchise owners are expertly trained in a proven business model. This unique opportunity offers multiple streams of revenue by helping business owners. More info

Build a thriving senior care business with heart. Multiple revenue streams, award-winning support, and a mission that makes a difference. More info

Work from home and build a scalable shipping business with UPS & DHL—low overhead, big income potential! More info

Tap into the huge demand for fresh, custom-made pet foods by owning this top-ranked pet franchise. More info

Leading Residential Property Management Franchise Seeking Like Minded Candidates. We provide an opportunity in Property Mgmt for those seeking a residual income and the lifestyle that accompanies it. More info

Ranked as a top Residential Cleaning franchise by 2026 Entrepreneur Franchise 500®. 91% recurring customers!* More info

ComForCare is your chance to own a senior home care franchise business that makes a real, meaningful difference in the lives of older adults in your community. Our franchise owners help families find peace of mind, knowing that their loved ones want to live their best life possible in the comfort of their own home. More info

Are you passionate about owning your own business? Are you interested in giving people the choice to eat healthy? If the answer is yes, then you have found the right partner to build you a successful healthy vending business. At Healthier4U Vending we share your passion and want you to join us to give the choice to eat healthy to everyone. Come see how together we can change your life. More info